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CGRP Inhibitors
CGRP Inhibitors: Understanding Uses and Side Effects
CGRP inhibitors are a relatively new class of medications that have been developed specifically for the treatment of migraines. In this article, we'll explore what CGRP inhibitors are, how they work, and which ones are approved for use in Australia, as well as their potential adverse effects and contraindications.
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What are CGRP inhibitors?
CGRP inhibitors are a class of medications that target the calcitonin gene-related peptide (CGRP), a molecule that is believed to play a role in the development of migraines. These medications work by blocking the action of CGRP or the CGRP receptor, which can help reduce the frequency and severity of migraines.
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Which CGRP inhibitors are TGA approved in Australia?
In Australia, there are currently three CGRP inhibitors that are TGA approved for the treatment of migraines:
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Erenumab (Aimovig)
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Fremanezumab (Ajovy)
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Galcanezumab (Emgality)
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All three medications are administered via subcutaneous injection. The frequency is determined by your doctor.
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Who qualifies for CGRP inhibitor therapy under the PBS?
To qualify for CGRP inhibitor therapy under the PBS, patients must meet certain criteria, including:
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A diagnosis of chronic migraine or episodic migraine with at least four migraine days per month
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Previous failure of at least three other migraine prophylactic medications
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A positive response to a CGRP inhibitor trial
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Must be initially prescribed by a Neurologist
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What are the potential adverse effects and contraindications of CGRP inhibitors?
While CGRP inhibitors are generally well-tolerated, they can cause some adverse effects in some people. Common adverse effects may include injection site reactions, constipation, and muscle spasms.
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CGRP inhibitors should not be used in certain situations, such as during pregnancy or in people with a history of hypersensitivity reactions to the medication. They may also interact with certain medications, so it's important to talk to your healthcare provider before taking CGRP inhibitors for migraines.
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In summary, CGRP inhibitors are a relatively new class of medication that have been developed specifically for the treatment of migraines. In Australia, there are currently three TGA approved CGRP inhibitors, which are administered via subcutaneous injection. Patients must meet certain criteria to qualify for CGRP inhibitor therapy under the PBS. While CGRP inhibitors are generally well-tolerated, they may cause adverse effects in some people and should not be used in certain situations, so it's important to talk to your healthcare provider before taking CGRP inhibitors for migraines.
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If you suffer from headaches or migraines, it's important to get advice from a qualified healthcare professional. The Headache Clinic is a specialised clinic in North Sydney that focuses on the diagnosis and management of headaches and migraines. We also serve patients all across Australia via telehealth.
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The Headache Clinic has a team of experienced headache-specialist Neurologists who can provide expert guidance on the best treatment options for your individual needs. We understand that headaches and migraines can be really bad and we prioritise urgent appointments for those in need. We offer appointments within 1 week of booking, so you can get the care you need as soon as possible.
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To book an appointment with one of our headache-specialist Neurologists, you can call (02) 9745 9852 or book online through our website. Our clinic is conveniently located in Sydney and offers a comfortable and welcoming environment for patients. Don't let headaches or migraines control your life – contact The Headache Clinic today to start feeling better.